This quote is referring to the feeling of vertigo, which is a type of motion sickness where one has the sensation of spinning, or falling. It can be caused by looking down from a great height, like from a tall building or mountain. The quote suggests that anyone whose ambition is to achieve something greater than themselves may experience vertigo as they work towards their goal. Vertigo can be seen as a voice that tempts and lures us to give up, and it takes courage to fight the feeling and go for what one desires.