I really hate sitcoms on television with canned laughter and stuff. What really makes me laugh is the real-life stuff. I've got a dry sense of humor.

This quote is saying that the speaker does not like sitcoms that have added sound effects of people laughing (canned laughter). They prefer to laugh at real-life situations and have a dry sense of humor, which means that it’s often subtle and witty, but not necessarily funny.