This quote means that when things are difficult, people who know how to navigate difficult times will rely on hard work, close friends, humor, and prayer as tools to help them get through it. They build a network of people and resources to help them out during hard times. This support network can include friends and family they can talk to, advice they can get from their prayer, and laughter to lighten the mood when things get tough. With this support network, they can get through anything.