This quote is about not giving up, even when faced with failure. The speaker is saying that he is not afraid to fail, because he knows that if he fails over and over again, he is more likely to succeed. He gives an example by saying that he has missed many shots and lost many games, but he has also had the opportunity to take the game winning shot 26 times – meaning that he has been successful enough times to keep trying. The message is that failure is a natural part of life, and that it should not be a cause for discouragement, but rather the motivation to keep pushing forward and achieving success.