Pain and suffering are always inevitable for a large intelligence and a deep heart. The really great men must, I think, have great sadness on earth.

This quote suggests that people with high intelligence and a kind heart will always suffer from pain and suffering. Such people, the quote suggests, feel more deeply than other people, and because of this they have to go through difficult times. The quote also suggests that somebody who is respected as a “great man” must also accept sadness in their life. In other words, even those people who are highly successful and respected will experience pain and suffering in their lives.