The thing that makes 'Dirty Jobs' different is that it's one of the few shows that portrays work in a way that doesn't highlight the drudgery. Instead, it highlights the humor.

This quote means that what makes the TV show called “Dirty Jobs” unique is that it doesn’t focus on the difficult and dull aspects of work; instead, it focuses on the humourous moments. This is different from most other TV shows that focus on the boring tasks associated with a job.